Molecular Hydrogen Therapy for Management of COVID-19: Review by Ministry of Health of Malaysia
This rapid assessment was prepared by the Ministry of Health to provide urgent evidence-based input during COVID-19 pandemic. The report is prepared based on information available at the time of research and a limited literature. It is not a definitive statement on the safety, effectiveness or cost effectiveness of the health technology covered. Additionally, other relevant scientific findings may have been reported since completion of this report.
Molecular hydrogen (H2) has been proposed to have therapeutic and preventive effects for variety of diseases. Its applications range from acute illness such as ischaemia–reperfusion injury, shock and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis and neurodegenerative diseases.1 There is a growing evidence obtained by animal model experiments on molecular hydrogen (H2) as antioxidant, anti-inflammatory, antiapoptotic and antiallergic.2-9 The claimed benefits were demonstrated through various delivery methods including drinking H2 rich water, intra-peritoneal injection, infusion of H2-rich saline, taking an H2 bath, dropping H2-saline onto the eyes and inhalation.(Table 1) 5, 6, 10-15 However, inhalation of hydrogen gas has been established as the easiest and simplest route of administration. It also allows monitoring of the dose of hydrogen. As a biological gas, hydrogen has the ability to diffuse freely across biological membranes, acting in various functional capacities.16, 17